Efek Hipoglikemia Ekstrak Etanol Biji Mahoni (Swietenia mahogani Jack.) dan Gambaran Mikrostruktur Limpa pada Mencit (Mus musculus L.) yang telah Diinduksi Diabetes dengan Aloksan

Abstract

A research was conducted to investigate antidiabetic activity of ethanol extracts from the seed of mahogani (Swietenia mahogany Jack.) and microstruktur in the mice was inducted diabetic with alloxan. The experiment used completely randomized design (CRD) with 5 treatments and 5 replications. Diabetes mellitus was induced in 16 hours fasted animals by a single intraperitoneal injection of 5,04 mg alloxan. Twenty five mice were divided into 5 groups., i.e. KN (normal mice); KP (diabetic mice); and P1, P2, and P3 were diabetic mice treated respectively with 1.4, 2.8, and 4.2 mg/kg bw Mahogany seed extract. The result showed that the extract of 2,8 mg/kg bw and 4,2 mg/kg bw was able to decrease blood glucose level (P<0,05), but the extract was not able recovery decreasing body weight of diabetic mice. The extract also was able impact on microstructure of spleen. In conclusion, we suggested that ethanol extracts of Swietenia mahogany seed is able to decrease blood glucose level in alloxan inducted diabetic mice.