Pengaruh Ekstrak Metanol Daun Suren (Toona sureni Bl Merr.) terhadap Fungsi Hati dan Nilai Darah Tikus (Rattus norvegicus L.) Jantan yang Dipapari Karbon Tetraklorida (CCl4)

Abstract

The effect of methanol extract of suren leaves (Toona sureni BL Merr) on the function of liver, erythrocyte count and haemoglobin level in male rat (Rattus norvegicus) induced by carbon tetracloride (CCl4) had been studied from April to November 2015. This research performed with completely randomized design and treatment was divided into 8 groups: 2 groups of positive control, 2 groups of solvent control, normal control, and 3 groups of extract concentration (100, 150 and 200 mg/kg/bw). The rats were exposed to CCl4 for 10 days and followed by suren extract for 14 days and the blood sample collected from the heart by cardiac puncture method. The result showed methanol extract of suren leaves decreased SGPT level and increased erythrocytes count significantly at 100 mg/kg/bw.