Efek Alprazolam terhadap Perilaku Kognitif dan Psikomotorik pada Mencit (Mus musculus L.) dengan Menggunakan Alat Sistem Otomatis Intellicage

Abstract

Alprazolam is an effective medicine that acts as anxiolytic and other drugs in the treatment of depression but have adverse side effects, including cognitive impairment (memory), and psychomotor. This research aims to determine the effect of drugs on cognitive behavioral alprazolam (memory) and psychomotor mice (Musmusculus) using Intellicage. The variable covers the number and duration of the visit, number and duration of nosepokes, as well as the number and duration of licking on learning corner. 12 mice’s were divided into four groups: blank control, saline control, treatment of alprazolam and saline, and treatment of saline and alprazolam. Mice were fasted for 18 hours, then they were observed for six hours later by directing them only to one corner, they were given access to drinking and punishment in the form of air-puff. The result showed that alprazolam impaired cognitive function (memory) and there is significant difference in the number of visits and nosepoke at the learning corner (p<0,05). Alprazolam can cause interference damages cognitive function and psychomotor mice (Musmusculus).