| dc.description.abstract | Noise is one of stressor that can lead to many health problems among other
disorders of the immune system, hormone system, digestive system, increase
blood pressure, etc. Mangosteen peel extract contains compound such as
xanthones which can reduce the disorder. The purpose of this research is to
investigate the effect of mangosteen peel extract on gaster histological rat exposed
to noise. This study was an experimental study using Completely Randomized
Design (CRD) with 5 treatment groups and 5 replications. This study was used
positive control of mangosteen peel extract from the 1st day until 16th
day and
negative control of distilled water from the 1st day until 16th day and noise 85-110
dB from 9th day to 16th day. The next groups were given a mangosteen peel extract
from the 1st day until 16th day and then given noise with different noise levels,
namely: 25-50 dB, 55-80 dB and 85-110 dB from 9th
day to 16th day. The volume
of mangosteen peel extract given was 0.5 ml/oral/day. Gaster made into
microscopic slides for histologic examination using paraffin method and
Hematoxyline Eosin (HE) stain. Morphologic examination showed color change
in P1 and P4 treatment groups. No significant difference was observed in rats
weight between treatment and control group. Histologic examination of the depth
of gastric mucosal erosion/gastric ulcersrats showed significant (P<0.05) decrease
of erosion between treatment and control group, but no significant decrease of
gastritic (P>0,05). | en_US |
