Uji Disolusi Kapsul Kloramfenikol secara Spektrofotometri UV-Visible yang di Produksi oleh PT. Kimia Farma (Persero) Tbk. Plant Medan

Abstract

Chloramphenicol is a broad-spectrum antibiotic that is active against gram positive and gram negative bacteria that are currently used by people to treat these types of infections due to bacteria by inhibiting protein synthesis required for the formation of the bacterial cells widely. The purpose of this test is to determine whether Chloramphenicol capsules produced by PT. Kimia Farma (Persero) Tbk. Plant Medan has been fulfilled dissolution test of the requirements as determined by the Pharmacopoeia Edition V. Chloramphenicol capsules must go through a series of tests to determine the quality of the capsule. One of the test is the dissolution test. Where dissolution is a process of transfer of drug molecules from the solid become the solution medium. The sample consisted of six capsules taken from a single batch. Dissolution test was performed by using a type of basketball (basket method) and the assay solute conducted by using UV-Visible spectrophotometry. So from the test results shown that the levels of solute from all six tablets capsule chloramphenicol 250 mg examined are 91.715%, 96.181%, 96.250% 92 900%, 97.836% and 95.091% with high levels of solute average capsule chloramphenicol 250 mg 95.091% is in accordance with the limits set in the Indonesian Pharmacopoeia Edition V.