Perbedaan Ekspresi Imunohistokimia, Reseptor Vitamin D (VDR) pada Wanita Penderita Mioma Uteri dan Wanita Non Mioma Uteri di RSUP Haji Adam Malik Medan

Abstract

Background : The effects of vitamin Dare mediated through vitamin D receptors (VDR). The uterine myoma show reduced VDR immunohistochemical expression compared with the normal uterinewithout uterine myoma. Objective: To determine the difference ofVDR immunohistochemical expression in women with uterine myoma and non-uterine myoma Method: Analytical research 2 research subjects paired with case control design using 20 samples blocks of paraffin uterine myoma and 20 samples blocks of paraffin non uterine myoma. We measured the intensity of immunohistochemical expression of Vitamin D receptors and then analyzed statistically. Results: Of the characteristics, in the uterine age group aged 40-49 years (65%) and the lowest age of20-29 years old (5%), found 17 (85%) people menarche at age ~14 years while the remaining 3 People (15%) had menarche over 14 years, Judging from the status of menopause in the myoma group found as many as 17 people (85%) had not menopause while the remaining 3 people (15%) had menopause, parity got the same amount in the myoma group and non myoma with the most multiparas (60%) and the rest of grandemultipara 40%, there were 13 people (65%) with normoweight and 7 people (35%) with overweight. According to its location can be seen that most cases of myoma come from submucosum (45%) and others from subserosum (35%) and intramural as much as 20%. The female group of uterine myomas had negative VDR expression as much as 19 people (95%) and 1 women of uterine myoma group had positive VDR expression (5%) whereas in the women who did not have uterine myoma all had positive VDR expression (100%). Statistically, there was a significant relationship between VDR expression and myoma incidence with p value <0,05. Conclusion: The female group of Mioma uteri had negative VDR expression as much as 19 people (95%) and 1 women of uterine myoma group had positive VDR expression (5%)

Latar belakang: Efek vitamin D dimediasi melalui reseptor vitamin D (VDR). mioma uteri menunjukkan ekspresi imunohistokimia VDR yang berkurang dibandingkan dengan uterus normal tanpa ada mioma uteri. Tujuan: Untuk mengetahui perbedaan ekspresi imunohistokimia VDR pada wanita penderita mioma uteri dan wanita non mioma uteri. Metode: Penelitian analitik 2 subjek penelitian yang berpasangan dengan desain case control menggunakan 20 sampel blok paraffin mioma uteri dan 20 sampel blok paraffin non mioma uteri. Kami mengukur intensitas ekspresi imunohistokimia reseptor Vitamin D dan kemudian dianalisa secara statistik. Hasil: Dari karakteristik, pada kelompok mioma uteri usia 40-49 tahun (65%) dan terendah dengan usia 20-29 tahun (5%), dijumpai sebanyak 17 orang (85%) mengalami menarche di usia S14 tahun sedangkan sisanya sebanyak 3 orang (15%) mengalami menarche di atas 14 tahun, Dilihat dari status menopause pada kelompok mioma dijumpai sebanyak 17 orang (85%) belum menopause sedangkan sisanya sebanyak 3 orang (15%) mengalami menopause, paritas · didapatkan jumlah yang sama pada kelompok mioma dan non mioma yaitu terbanyak dengan multipara (60%) dan sisanya grandemultipara sebanyak 40%,pada kelompok mioma ada sebanyak 13 orang (65%) dengan normoweight dan sebanyak 7 orang (35%) dengan overweight. menu rut lokasinya dapat dilihat bahwa sebagian besar kasus mioma berasal dari submukosum (45%) dan lainnya dari subserosum (35%) dan intramural sebanyak 20%. Kelompok wanita Mioma uteri mempunyai gambaran ekspresi VDR negatif sebanyak 19 orang (95%) dan 1 orang kelompok wanita mioma uteri mempunyai gambaran VDR positif (5%) sedangkan pada kelompok wanita yang tidak menderita Mioma uteri seluruhnya mempunyai gambaran ekspresi VDR positif (100%). Secara statistik dijumpai adanya hubungan yang bemakna antara ekspresi VDR dengan kejadian mioma dengan nilai p < 0,05. Kesimpulan:. Kelompok wanita Mioma uteri mempunyai gambaran ekspresi VDR negatif sebanyak 19 orang (95%) dan 1 orang kelompok wanita mioma uteri mempunyai gambaran VOR positif (5%)