Efek Pemberian Kombinasi Ekstrak Allium Sativum, Curcuma Longa dan Zingiber Officinale terhadap Perubahan Kadar Vascular Endothelial Growth Factor (VEGF) Serum Pasien Kanker Payudara

Abstract

Introduction : Breast cancer requires high nutrition, oxygen and metabolism where VEGF-triggered angiogenesis is needed. VEGF is triggered via the HIF-1 pathway and also via the NF-Kappa B pathway. VEGF is associated with tumor growth and metastasis. Some plant extracts have anti-angiogenesis effects such as Curcuma longa, Allium sativum and Zingiber officinale. Objective: To determine serum levels of SGOT, SGPT, ureum, creatinine, albumin and VEGF before and after administration of Curcuma longa, Allium sativum and Zingiber officinale extracts Method : An open label clinical trial study with a one group pretest posttest design involving 21 patients from breast cancer community in Medan collected by consecutive sampling in USU hospital where these patients met the inclusion criteria. All patients were tested for complete blood count, urea, creatinine, SGOT, SGPT, albumin, serum VEGF before and after being given an extract combination of Curcuma longa 150 mg, Allium sativum 200 mg and Zingiber officinale 150 mg twice daily for 28 days. Statistical analysis was performed by paired analytical T test or Wilcoxon. Results: The study involved 20 subjects. From the examination of kidney function obtained results before and after the administration of a combination extract VEGF results before and after the administration of the combination (1110(760-7893) μg / ml vs. 864 (532- 5650 μg / ml, p = 0.001). Conclusion: VEGF serum breast cancer patients had a significant reduction after being given a combination of extracts of Allium sativum, Curcuma longa and Zingber officinale.