Korelasi Nilai Parathyroid Hormone (PTH) terhadap Nilai Kalsium, Magnesium, Fosfat sebagai Marker Inflamasi pada Pasien Penyakit Ginjal Kronik (PGK) dengan Hemodialisis Reguler

Abstract

Introduction: Chronic Kidney Disease (CKD) is a pathophysiological process with various etiologies that causes a progressive decline in kidney function and ends with kidney failure. [1] CKD is a health problem that occurs in society and has covered globally. Global Burden of Disease 2010 stated that CKD was the 27th cause of death in the world in 1990. This figure increased to 18th in 2010. Parathyroid hormone is a potential factor for anemia in CKD patients. In CKD patients, there is an increase in parathyroid hormone levels, which is a uremic toxin that affects calcium, magnesium, and phosphate levels in serum. Elevated levels of parathyroid hormone in patients with chronic kidney disease have been studied extensively by various clinical observational studies. This study aims to determine the correlation between parathyroid hormone (PTH) levels and calcium, magnesium, phosphate values in chronic kidney disease (CKD) patients undergoing regular hemodialysis at Haji Adam Malik General Hospital. Methods: This study is an analytical study with a cross-sectional design. A total of 45 research subjects met the inclusion and exclusion criteria, anamnesis, physical examination, anthropometry, and laboratory tests were performed to measure levels of parathyroid hormone, calcium, magnesium, phosphate, and albumin. Data analysis was performed using SPSS. Results: PTH levels measured had a minimum value of 113 pg/ml and a maximum of 595 pg/ml with an average of 431.4. The minimum calcium value is 5.4 mg/dl and the maximum is 9.6 mg/dl, while the magnesium value is at least 1.6 mg/dl and the maximum is 2.6 mg/dl, while the phosphate value is at least 3.5 mg/dl and the maximum 8.8 mg/dl. The Mann-Whitney U test showed no significant relationship between PTH and calcium levels with a significant p-value of 0.993 (p-value <0.05), PTH-magnesium levels with a significant p-value of 0.809 (p- value <0.05), and levels PTH with phosphate with a significant p value of 0.293 (p value <0.05). Conclusion: Parathyroid hormone has no statistically significant relationship with calcium, magnesium, phosphate values in CKD patients undergoing regular hemodialysis.