| dc.description.abstract | Background:Matrix metalloproteinase-9 (MMP-9) is a member of
metalloproteinase enzymes that are often found in colorectal adenocarcinoma.
MMP-9 is able to destroy basement membrane and extracellular matrix proteins
that play a role in tumor cell invasion.
Destination: This study was conducted to analyze the relationship between MMP-
9 expression and the clinicopathological characteristics of colorectal
adenocarcinoma NOS.
Method:The study used 30 paraffin block samples of adenocarcinoma colorectal
NOS cases that had been diagnosed at the Laboratory of Anatomic Pathology, H.
Adam Malik Hospital, Medan and at the Department of Anatomic Pathology,
Faculty of Medicine, University of North Sumatra. MMP-9 expression was assessed
using immunohistochemical staining of the cytoplasm of tumor cells and cells of the
stroma. Expressions were assessed using the Quick Score method and were
declared weak when the total score was 0-5 and strong when the total score was 6.
Statistical analysis between MMP-9 expression and the depth of invasion was
performed using Fisher's Exact and Mann-Whitney U tests.
Results:MMP-9 expression was significantly related to stage (p=0.01), depth of
invasion (p=0.03), and stromal Tils (p=0.03) and not significantly related to gender
(p=0.28). , age (p=0,82), tumor location (p=0,69), grading (p=0,26), lymph node
involvement (p=0,53), metastasis (p=0,53), perineural invasion (p=0.25),
lymphatic invasion (p=1.00), IMVI (p=0.531.00), EMVI (p=1.00), tumor budding
(0.25)
Conclusion :MMP-9 expression can be used as a prognostic indication and also
helps clinicians, especially in the management of patients with colorectal
adenocarcinoma NOS. | en_US |
