| dc.description.abstract | Background: Stretch marks or striae distensae is a skin disorder that cause cosmetic and
psychological problem. Pumpkin (Cucurbita moschata) is widely cultivated in Indonesia.
Pumpkin seeds contain ascorbic acid, flavonoids, beta-carotene, linoleate, and linolenate
acid which play a role in the repair of stretch marks through anti-inflammatory
mechanisms, increase fibroblast proliferation, increase collagen production, increase
crosslinking between collagen fibers and moisturizer.
Objective: To determine the effect of 5% pumpkin (Cucurbita moschata) seed extract
cream on stretch marks.
Subject and Methods: This study is a quasi experimental clinical trial with a pretestpostest
research design on 31 subjects with stretch marks. Diagnosis was confirmed by
history and clinical evaluation using the Manchester scar scale before and after
administration of 5% pumpkin seed extract cream alone and combination of 5% pumpkin
seed extract cream and 0,1% tretinoin cream at week 0, 2, 4, 6, and 8. Adverse effects
were recorded during the study and satisfaction levels were assessed at the end. In
addition, a Friedman test was carried out to see the difference before and after treatment
with a p <0.05, was considered significant.
Results: The majority of subjects ages ranged from 18 to 25 years (87%). There was a
significant decrease in Manchester scar scale in stretch marks, both after being given 5%
pumpkin seed extract cream or combined with 0,1% tretinoin cream for 8 weeks
(p<0,001). Stretch marks after being given 5% pumpkin seed extract cream compared to
5% pumpkin seed extract cream combined with 0,1% tretinoin cream, there was no
significants difference (p<0,251). Of the total 31 subjects, none experienced side effects.
Based on the level of satisfaction all subjects feel satisfied.
Conclusion: The use of 5% pumpkin seed extract cream can improve the appearance of
stretch marks without side effects and the all subjects feel satisfied. | en_US |
