Hubungan Lama Pemakaian Kelasi Besi terhadap Biokimia Profil Tulang pada Pasien Talasemia

Abstract

Background: Thalassemia is a genetic hematologic disorder that needs a lifetime transfusion. It will cause heart disease, endocrinopathies including abnormalities of bone profile. Study in Mosul show that association between duration of iron chelation agent and biochemical bone profiles (alkaline phosphatase) Objective: To determine the effect of longterm use of iron chelating agent to biochemical bone profile in thalassemia patients. Methods: A cross sectional study was conducted in Haji Adam Malik hospital and Sari Mutiara hospital Medan, on July until September 2015. Biochemical bone profile measurement were performed to all subjects. Data was analyzed using Spearman correlation test and P value less than 0.05. Results: 33 thalassemia children were enrolled this study. Mean age of the subject was 1 O years old (SD: 3.90), and the mean time of using iron chelation was 6 month (SD: 3.42). Bone profile measurement showed that mean level of calcium was 9 mg/DI (SD: 0.86), phosphor was 4.6 mg/DI (SD: 0.66), alkaline phosphatase was 293.2 IU/L (SD:157.40), and serum albumin was 3.8 g/DI (SD:0.50) . Spearman correlation test showed no significant correlation between duration of iron chelation agent and biochemical bone profiles (P: >0.05). Correlation for each association between duration of iron chelation agent used and bone profile were as follows calcium (r=0.196), phosphor (r = -0.219), alkaline phosphatase (r = 0.251), and albumin (r = 0. 155) there was weak correlation. Conclusion: Longterm used of iron chelating agent has weak correlation with biochemical bone profile in thalassemia patients