Hubungan Kadar High Sensitivity C-Reactive Protein (hs-CRP) dengan Derajat Keparahan Dermatitis Atopik pada Anak

Abstract

Background: Atopic dermatitis (AD) is a chronic episodic skin disorder, with systemic inflammatory conditions. The high sensitivity c-reactive protein (hs-CRP) level was measured as a marker of low-grade inflammation to determine the relationship between low-grade inflammation and AD severity. Objective: To determine the correlation between hs-CRP levels and severity of AD in children. Subjects and methods: Observational analytic study with a cross-sectional approach to 30 subjects aged ≤17 years with AD. Recording of basic data and subject examination includes assessing the severity of AD using the Scoring Atopic Dermatitis (SCORAD) score and measuring hs-CRP levels. Data analyzed by Pearson correlation test. Result: Averaged hs-CRP level of subjects with AD was 3,881,07 mg/L with the lowest level 2.43 mg/L and the highest level was 6.03 mg/L. The highest age with AD was 6-10 years group about 15 (50%) subjects and the lowest age was aged 1-5 years group about 6 (20%) subjects. In this study was found that the subjects were dominated by boys as many as 20 subjects (66.7%), and girls about 10 subjects (33.3%). Family history of atopy was found in all subjects (100%). The mean SCORAD score was 21,636,41. The difference in hs-CRP levels was found to be higher in the more severe AD severity. Averaged hs-CRP level in the group of subjects with mild severity was 3.44 mg/L while in the group of subjects with moderate severity 4.9 mg/L. There is a significant relationship between hs-CRP and SCORAD and there is a positive correlation with a moderate level of strength between hs-CRP and SCORAD (p <0,001, r = 0,509) Conclusion: There is a significant relationship between hs-CRP and SCORAD and there is a positive correlation with a moderate level of strength between hs-CRP and SCORAD