Gambaran Histologi Ginjal Mencit (Mus musculus L.) Jantan yang Diberi Limbah Degumming Kokon Ulat Sutera (Bombyx mori L.) yang Telah Dipapar Allethrin

Abstract

Serisin is one of the proteins contained in silkworm cocoon degumming which functions as an antioxidant. The study aimed to analysed the effect of degumming waste of silkworm cocoons (Bombyx mori L.) on the morphological and histological improvement of the kidneys of male mice (Mus musculus L.) exposed to allethrin. The research method designed by a completely randomized design (CRD) consisting of 5 treatments, which were allethrin exposure only; allethrin exposure and combined by vitamin C; allethrin expore with degumming waste of silkworm cocoons at different doses of 100, 200 and 300 mg/BW. This study used 25 male rats (Mus musculus L.). The research observed kidney morphology including the shape, the colour, the texture, the weight and the volume of the kidney as well as kidney histology including the glomerular area, the proximal tubular narrowing and the kidney necrosis. The results of the research showed the silkworm cocoon degumming waste could improve the colour, the texture, increasing the glomerular area, reducing the amount of proximal tubular constriction and reducing the amount of kidney necrosis due to exposure to allethrin. The Silkworm cocoons degumming waste at a dose of 300 mg/kgBW showed the best dose in improving the morphological and histological features of the kidneys of male mice (Mus musculus L.) exposed to allethrin.