| dc.description.abstract | The nanoherbal gagatan harimau leaf (Vitis gracilis Wall.) contains secondary
metabolite compounds like flavonoids that can lessen the severity of liver lessions.
Hepatocyte cells can suffer harmly from oxidative stress but can be reduced by
flavonoids. Flavonoids direct free radical adsorption and function as antioxidants. In
this research, male Wistar rats (Rattus norvegicus L.) that had received physical
exercise were given a nanoherbal extract of gagatan tiger (Vitis gracilis Wall.) leaf to
see the affects on the liver histology. The experiment was used completely randomized
design (CRD) by six treatments, each of them contains four replications, The treatment
consisted of negative control (normal rats); positive control (20 minutes of swimming
exercise); 20 minutes of swimming exercise + 2 mg/kgBW of Vitamin C mixtured
by100 mg/kgBW of gagatan tiger nanoherbal leaf (Vitis gracilis Wall.); 125 mg/kgBW,
and 150 mg/kgBW. Liver histology was made by paraffin method with Hematoxylin Eosin (HE) staining. The results showed that the 20 minutes swimming caused
oxidative stress which could cause damage to liver hepatocyte cells such as
parenchyme degeneration, hydropic degeneration, and necrosis. Giving nanoherbal
gagatan tiger leaf (Vitis gracilis Wall.) looked like to heal the hepatocyte cell damage
even after 20 minutes of vigorous swimming. The optimum dosage of gagatan tiger
leaf nanoherbal (Vitis gracilis Wall.) was 125 mg/kgBW because it exhibited cell
regeneration that was comparable to the normal treatment group | en_US |
