Uji Efektivitas Nanoherbal Daun Gagatan Harimau (Vitis Gracilis Wall.) Terhadap Histologi Jantung pada Tikus Wistar (Rattus Norvegicus L.) Jantan yang diberi Latihan Fisik

Abstract

Gagatan harimau (Vitis gracilis wall.) is one of the Indonesian plants that has bioactive compounds and is beneficial as an antioxidant. In order to get the maximal effects, it need a specific preparation of this nanoherbal product. The study aimed find out the effectiveness of Gagatan harimau leaves (Vitis Gracilis Wall.) on the body weight, morphology and the histology of the heart in male wistar rats (Rattus norvegicus L.) which were given maximal exercise. The study consists of six treatments using a Complete Random Plan (CRP): (1) Negative Control (only given feed ad libitum); (2) Positive Control (only given maximal exercise); (3) Maximal Exercise + Vit. C 2 mg/kgBW; (4) Maximal Exercise + 100 mg / kgBW nanoherbal leaves of Gagatan harimau (Vitis gracilis Wall.); (5) Maximal Exercise + 125 mg/kgBW nanoherbal leaves of Gagatan harimau (Vitis gracilis Wall.); (6) Maximal Exercise + 150 mg/kgBW nanoherbal leaves of Gagatan harimau (Vitis gracilis Wall.). The research was conducted by the paraffine and coloring methods of Hematoxiline-Eosin (HE). The results showed the leaves of Gagatan harimau (Vitis gracilis Wall.) at a dose of 125 mg/kgBW affected the body weight, the morphology and as well as the histology of the heart.