Korelasi antara Nilai Red Blood Cell Distribution Width (RDW) dengan Tingkat Keparahan Sepsis

Abstract

Background: Sepsis is a pro-inflammatory state caused by systemic infection. As sepsis progresses, multiple organ systems become affected with subsequent increase in mortality. Elevated red cell distribution width (RDW) has been noted with changes of other inflammatory markers and thus could potentially serve as a means of assessing sepsis severity. In this study, we examine the correlation between RDW with sepsis severity. Objective: To determine differences between RDW value in infection without sepsis and sepsis patients, sepsis and severe sepsis patients. Also to determine the relationship between RDW with AP ACHE II score Methods: Cross-sectional study was conducted on 41 patients with infection (27 men and 14 women) that had been admitted to H. Adam Malik hospital from February 2016 to June 2016. Patients were categorized into three group namely infection without sepsis, sepsis and severe sepsis based on clinical examination and laboratory test results. Grouping criteria sepsis base on Pedoman Nasional Pelayanan Kedokteran, Kemenkes 2014. Univariate and bivariate analysis (independent t-test and Chi Square) were done using SPSS V.17 Results: There was a significant difference of mean RDW between the sepsis and infection without sepsis groups (14,69 ± 2.31 and 13.39 ± 1.6, respectively) while for sepsis and severe sepsis group there was no significant difference of mean RDW. Likewise with AP ACHE II score, there was no significant difference between the two groups. Conclusion: RDW differed significantly between groups of sepsis and non sepsis infection, but did not differ significantly between groups of sepsis with severe sepsis