Hubungan Status Koagulasi terhadap Nilai Ankle Brachial Index (ABI) Penderita Penyakit Arteri Perifer dengan Diabetes Melitus

Abstract

Background: Diabetes mellitus (DM) is commonly associated with both

microvascular and macrovascular complications. Hyperglycemia, a well- defined risk factor for accelerated atherosclerosis and vascular disease,

may cause vessel damage and its resulting in glycalation of haemoglobin, prothrombin, fibrinogen and other proteins involved in clotting mechanisms. The glycation results in the incomplete activation and function of the clotting cascade. Diabetes mellitus is a risk factor for peripheral arterial disease (PAD) Objective: to determine correlation between coagulation status, ankle brachia! index (ABI) and PAD in patients with OM. Method: This is a observational analytic study that was performed in RSUP.H.Adam Malik Medan, from April to October 2015. All Sampels were examined Ankle Brachia! index (ABI) and coagulation parameters such: PT,APTT, Fibrinogen and D-dimer level. Result: There is significantly difference between fibrinogen and D-dimer level with PAD. OM patients with PAD had significantly higher fibrinogen and D-dimer levels compared with OM patients without PAD ( 333,35 ± 127,49 vs 244,95 ± 83,96; p=0,001) and ( 648,40 ± 443,96 vs 302,45 ± 108,41; p=0,008 ). There is significantly difference between fibrinogen and D-dimer level with severity of PAO, whereas severe PAD had significantly higher fibrinogen and D-dimer levels compared with mild PAD ( 374,00 ± 114,94 vs 327, 14 ± 136,45; p=0,012) and (1170,67 ± 398,72 vs 537,36 ± 348,08; p=0,012). Also there is negative correlation between O-dimer level and ABI values ( r -0,577; p=0,000). Conclusion: OM patients with PAD had significantly higher fibrinogen and D-dimer levels compared with DM patients without PAD. And there is negative correlation between D-dimer~evel and ABI values