| dc.description.abstract | Background: Diabetes mellitus (DM) is commonly associated with both
microvascular and macrovascular complications. Hyperglycemia, a well-
defined risk factor for accelerated atherosclerosis and vascular disease,
may cause vessel damage and its resulting in glycalation of haemoglobin,
prothrombin, fibrinogen and other proteins involved in clotting
mechanisms. The glycation results in the incomplete activation and
function of the clotting cascade. Diabetes mellitus is a risk factor for
peripheral arterial disease (PAD)
Objective: to determine correlation between coagulation status, ankle
brachia! index (ABI) and PAD in patients with OM.
Method: This is a observational analytic study that was performed in
RSUP.H.Adam Malik Medan, from April to October 2015. All Sampels
were examined Ankle Brachia! index (ABI) and coagulation parameters
such: PT,APTT, Fibrinogen and D-dimer level.
Result: There is significantly difference between fibrinogen and D-dimer
level with PAD. OM patients with PAD had significantly higher fibrinogen
and D-dimer levels compared with OM patients without PAD ( 333,35 ±
127,49 vs 244,95 ± 83,96; p=0,001) and ( 648,40 ± 443,96 vs 302,45 ±
108,41; p=0,008 ). There is significantly difference between fibrinogen and
D-dimer level with severity of PAO, whereas severe PAD had significantly
higher fibrinogen and D-dimer levels compared with mild PAD ( 374,00 ±
114,94 vs 327, 14 ± 136,45; p=0,012) and (1170,67 ± 398,72 vs 537,36 ±
348,08; p=0,012). Also there is negative correlation between O-dimer level
and ABI values ( r -0,577; p=0,000).
Conclusion: OM patients with PAD had significantly higher fibrinogen and
D-dimer levels compared with DM patients without PAD. And there is
negative correlation between D-dimer~evel and ABI values | en_US |
