Hubungan Kadar Serum Bilirubin Total dengan HbA1C pada Pasien DM Tipe 2 Terkendali dan Tidak Terkendali

Abstract

Background: HbAlc levels were higher in patients with diabetes is associated with increased risk of cardiovascular disease. Bilirubin is expected to act as an endogenous antioxidant and anti-inflammatory. Increased serum bilirubin was associated with a reduced risk of coronary heart disease and stroke. Objective: To determine correlation of serum total bilirubin and HbAlc in controlled and uncontrolled type 2 diabetes mellitus. Methods: This study is a cross-sectional observational analytic approach performed in RSUP.H.Adam Malik in February - March 2015. A sum of 50 samples were divided into 2 groups: Samples with controlled DM (HbAlc <7) and uncontrolled DM (HbAlc ?:_7) amounted to 25 people each. All samples were examined serum total bilirubin. Using statistical test unpaired student t test when distribution is normal, and if the distribution is not normal, we use Mann Whitney test with a significance p value <0.05 Results: In this study we obtained serum levels of serum total bilirubin in patients with HbAlc < 7 and HbAlc ?:_ 7 each 0.704 ± 0.299 and 0.560 ± 0.138. Although there are differences, but we found no correlation between total bilirubin serum levels and HbA 1 c in both groups (HbAlc <7, r = 0.119, p = 0.580 and HbAlc ?:_ 7, r = 0.234, p = 0.261) Conclusions: There was no correlation between serum total bilirubin and HbA le in both groups