Hubungan TNF-a dengan Derajat Keparahan Gastritis secara Histopatologi

Abstract

Introiluction. Helicobocter ori is the most common bactenal infection that cause gastric inflammation. It promotes neutrophils and monocyte recruitrnent, and many cytokines which causes gasfic mucosa damage. Although cytokine-based gastric mucosal immune response expres sion to H. pylori infection have been well documented, only few data. on circulating levels of particular inflammatory cytokines are available. Aim. The aim of this study was to see the correlation of serum levels of TNF-o with the degree of gastritis based on histopathology. Methods. This research is a cross sectional descriptive analltical study. Eighty gaskitis patients that fulfrlled the inclusion criteria underwent serurn TNF-o examination and biopsy. Rapid urease test was used for diagnosis of H. pylori infection. The severity of gasritis based on lymphocyte infiltration, neutrophil

infiltration, atrophy, and intestinal metaplasia were assessed from biopsy- Univanate and bivariate analysis (chi square, fishet's exac! spearman and

independent t test) were done using SPSS version-19. Resufts, There were 41.25% patients infected wifrr Helicobacter pylori. Serum TNF-o levels in th6 infected group were sigr.ificantly higher compared to negative

H. pylori (p<0 05). Therc were positive correlations between serum level of TNF- o and degree of chronic inflammation [F0,333 dengan p-value:0.003].

Conclusion. High level of TNF-o correlated with severe degree of gastritis based on infiltration of lymphocyte and the actrve infection of H. pylori