Hubungan High Sensitivity C-Reactive Protein terhadap Perbaikan Kapasitas Fungsional Pasca Rehabilitasi Jantung Fase II pada Pasien yang Menjalani Bedah Pintas Arteri Koroner di RSUP. H. Adam Malik Medan

Abstract

Introduction: Improved functional capacity is a good prognostic value in post-BPAK patients. Phase II cardiac rehabilitation improves metabolic parameters and improves functional capacity, and there is a significant decrease in hsCRP values in post-BPAK patients. Several studies have selected high-sensitivity CRP (hs-CRP) levels as a marker of inflammation that can be widely used to assess the beneficial effects of cardiac rehabilitation in inflammatory states. Objective : To determine the relationship between hs-CRP value and functional capacity improvement after phase II cardiac rehabilitation in patients undergoing coronary artery bypass surgery at H. Adam Malik General Hospital Medan Method: This study is an observational analytic study conducted prospectively on 29 patients undergoing phase II CABG cardiac rehabilitation. Functional capacity data were collected, hsCRP examination before and after phase II cardiac rehabilitation. Data were analyzed univariately and bivariately to assess the relationship between hsCRP and functional capacity. Then a multivariate analysis will be carried out using linear regression. Relationship test will be carried out with the Pearson correlation test. Statistical data analysis using SPSS software, p value <0.05 was said to be statistically significant. Result: There were 29 research samples. The results of the cardiac exercise test showed an increase in distance at the end of phase II cardiac rehabilitation compared to the initial examination (457.655 ± 24.346 vs 180.482 ± 13.941). At the end of the examination, there was a decrease in the average hsCRP level from 5.244 ± 0.482 to 0.475 ± 0.095. A significant relationship was found between functional capacity improvement and hsCRP (p=0.032, r=0.39). An increase of 1 MET hsCRP will result in a change in hsCRP of 0.082 mg/L. There was an average decrease in hsCRP from 5.244 ± 0.482 to 0.475 ± 0.095 at the end of phase II with a p value <0.001. Conclusion: There is a relationship between a decrease in hsCRP levels and an improvement in functional capacity after phase II cardiac rehabilitation in patients undergoing coronary artery bypass surgery at the Hospital. H. Adam Malik Medan