| dc.description.abstract | Background: Systemic Lupus Erythematosus (SLE) can involve various organ systems
including the nervous system with the most clinical manifestations being cognitive
impairment. Cognitive impairment is a hidden and often undiagnosed manifestation of
SLE but can seriously impair quality of life even in mild cognitive impairment.
Objectives: To determine the factors that affect cognitive function in patients with
systemic lupus erythematosus
Methods: This study was a cross-sectional study selected by consecutive sampling
technique, in which SLE patients who went to the internal medicine polyclinic at the
Haji Adam Malik General Hospital in Medan who met the exclusion and inclusion
criteria were included in the study. This research started from January to April 2024.
Results: this study was conducted on 50 SLE patients consisting of 48 women and 2
men with an average age of 34.90 ± 11.81 years. The mean duration of SLE is 4.18 ±
3.15 years. Based on the degree of SLE disease activity, the majority of mild degrees
were found in 35 people (70%). Based on the Moca-Ina score, 29 people (58%)
experienced cognitive impairment, 20 people (40%) got an abnormal TMT A score and
27 people (54%) got an abnormal TMT B score. On the GPT examination, the dominant
hand average was 76.56 ± 18.26 seconds, the non-dominant hand average was 84.42 ±
18.83 seconds, and the composite average was 161.16 ± 36.36. There were factors that
were significantly related to cognitive function based on the Moca-Ina score, namely
education (p=0.032), degree of SLE disease activity (p=0.004) and organ damage in
SLE patients (P=0.025), while based on TMT A scores and TMT B is organ damage in
SLE patients (p=0.017 and p=0.012). Based on the multivariate analysis of the factors
that affect cognitive function based on the Moca-Ina score, it was obtained that the more
dominant factor was the degree of SLE disease activity (p=0.024)
Conclusion: There are factors that significantly affect cognitive function in SLE
patients, namely education, degree of SLE disease activity and organ damage in SLE
patients. Based on the Moca-Ina score, the most influential factor was obtained, namely
the degree of SLE disease activity. | en_US |
