Hubungan Kepatuhan Minum Obat Kortikosteroid Oral Berdasarkan MMAS-8 dengan Skor SLEDAI pada Anak Systemic Lupus Erythematosus (SLE) di RSUP H. Adam Malik Medan

Abstract

Background: Childhood-onset SLE (cSLE) is difficult to diagnose that characterized by periods of flares and remissions.The SLEDAI score is one of the systems used to assess SLE activity. Long-term use of high-dose corticosteroids is associated with an increased risk of infection, metabolic and musculoskeletal diseases. This condition can cause non-adherence to taking medication in SLE patients. Medication adherence was assessed using the MMAS-8 Questionnaire. Objective: To determine the relationship between medication adherence of oral corticosteroids based on MMAS-8 score with SLEDAI scores in SLE children at H. Adam Malik Hospital Medan. Method: Using a cross-sectional method on 21 SLE children at Haji Adam Malik Hospital Medan who had received corticosteroid treatment for at least 3 months in May 2022 – July 2022. SLEDAI scores and adherence to corticosteroid medication were assessed using the MMAS-8 questionnaire. Result: A total of 21 samples were assessed for SLEDAI scores and adherence to taking corticosteroid medications using the MMAS-8 questionnaire. Most of the subjects showed a high level of compliance amounting to 9 people (42.9%). The results of the Kruskal Wallis test analysis showed that there was a significant relationship between the level of treatment adherence and SLE disease activity at control time (p = 0.002). The Wilcoxon test showed that there was no difference in the mean score of SLEDAI between before and after treatment (p = 0.057). Conclusion: There is a relationship between medication adherence of oral corticosteroids based on MMAS-8 score with SLEDAI scores in SLE children at H. Adam Malik Hospital Medan