Korelasi Lamanya Pemberian Obat Anti Bangkitan dengan Kadar Serum Vitamin D, Kalsium, Profil Lipid dan C-Reactive Protein pada Penderita Epilepsi di Rumah Sakit Umum Pusat Haji Adam Malik Medan dan Rumah Sakit Jejaring

Abstract

Background: The selection of anti-epileptic drugs (AED) should ideally take into account the side effect profile of the drug, the type of arousal, and most importantly the availability of the drug in the patient's living environment, AED affects mineral and bone metabolism by increasing vitamin D metabolism, leading to vitamin D deficiency. This deficiency inhibits calcium transport and absorption in the intestine, leading to hypocalcemia. Many studies have also shown that the use of AED that induce the cytochrome P450 (CYP450) system is associated with higher serum lipid levels and increased C-reactive protein (CRP). Objective: To determine the correlation between the duration of anti-epileptic drugs (AED) use and calcium, vitamin D, lipid profile and CRP in patients with epilepsy. Methods: This is an observational analytic study with a cross-sectional design. This research was conducted at Haji Adam Malik Hospital and network hospitals. The data used in this study are primary data in the form of laboratory examination results and secondary data sourced from medical records in the form of patient demographic data and patient treatment profiles. Results: In this study, there was a weak positive significant correlation between the duration of anti-epileptic drug treatment, total cholesterol (r=0,313; p=0,037), HDL (r=0,325; p=0,028), LDL (r=0,343; p=0,012), triglyceride (r=0,438; p=0,003) and c-reactive protein (r=0,321;p=0,032). It was also found that there was a weak negative significant correlation between duration of anti-epileptic drug treatment and vitamin D (r=-0.334; p = 0,025) and calcium (r=-0,320; p = 0,032) Conclusion: There is a weak positive significant correlation between the duration of anti-epileptic treatment and lipid profile and c-reactive protein. While there is a weak negative significant correlation between duration of anti-epileptic treatment and vitamin D and calcium.