| dc.description.abstract | Background: The selection of anti-epileptic drugs (AED) should ideally take into
account the side effect profile of the drug, the type of arousal, and most
importantly the availability of the drug in the patient's living environment, AED
affects mineral and bone metabolism by increasing vitamin D metabolism, leading
to vitamin D deficiency. This deficiency inhibits calcium transport and absorption
in the intestine, leading to hypocalcemia. Many studies have also shown that the
use of AED that induce the cytochrome P450 (CYP450) system is associated with
higher serum lipid levels and increased C-reactive protein (CRP).
Objective: To determine the correlation between the duration of anti-epileptic
drugs (AED) use and calcium, vitamin D, lipid profile and CRP in patients with
epilepsy.
Methods: This is an observational analytic study with a cross-sectional design.
This research was conducted at Haji Adam Malik Hospital and network hospitals.
The data used in this study are primary data in the form of laboratory examination
results and secondary data sourced from medical records in the form of patient
demographic data and patient treatment profiles.
Results: In this study, there was a weak positive significant correlation between
the duration of anti-epileptic drug treatment, total cholesterol (r=0,313; p=0,037),
HDL (r=0,325; p=0,028), LDL (r=0,343; p=0,012), triglyceride (r=0,438;
p=0,003) and c-reactive protein (r=0,321;p=0,032). It was also found that there
was a weak negative significant correlation between duration of anti-epileptic
drug treatment and vitamin D (r=-0.334; p = 0,025) and calcium (r=-0,320; p =
0,032)
Conclusion: There is a weak positive significant correlation between the duration
of anti-epileptic treatment and lipid profile and c-reactive protein. While there is a
weak negative significant correlation between duration of anti-epileptic treatment
and vitamin D and calcium. | en_US |
