Perbedaan Kadar VEGF (Vascular Endothelial Growth Factor) dan IGF-1 (Insulin like Growth Factor-1) pada Pasien Diabetes Melitus Tipe 2 yang Terkontrol dan Tidak Terkontrol di Puskesmas Padang Bulan Kota Medan

Abstract

Background: Diabetes Mellitus is a metabolic disorder characterized by an increase in blood sugar due to decreased insulin secretion by pancreatic beta cells or impaired insulin function (insulin resistance) which can result in endothelial damage. VEGF levels are associated with the incidence of microvascular complications in the form of diabetic retinopathy and diabetic nephropathy. Meanwhile, IGF-1 levels are related to the incidence of macrovascular complications, namely atherosclerosis. Research objective: to analyze differences in levels of VEGF (Vascular Endothelial Growth Factor) and IGF-1 (Insulin Growth Factor-1) in controlled and uncontrolled type 2 DM. Research method: Observational research design with Crosssectional Study. The research population was type 2 DM at the Padang Bulan Health Center, Medan City with a sample size of 52 people. The data source for this research is primary data. Examinations carried out included HbA1c using the HPLC method, measurement of VEGF and IGF-1 levels using the Bioassay Technology Laboratory ELISA Human IGF-1 and VEGF. Analysis uses the Independent T Test statistical test using the SPSS application. Research results: Of the 52 patients who were examined, it was found that 10 patients had controlled type 2 DM and 42 patients had uncontrolled type 2 DM. Uncontrolled type 2 DM had higher VEGF levels of 409 (ng/ml) than controlled 391.8 (ng/ml) with a value of (p= 0.9 p>0.05). IGF-1 levels in uncontrolled type 2 DM were higher at 8.4 (ng/ml) than controlled type 2 DM 6.6 (ng/ml) with a value of (p= 0.2 p>0.05). IGF-1 levels in non-obese type 2 DM were higher at 9.2 (ng/ml) compared to obese type 2 DM 7.0 (ng/ml) with a value of (p= 0.2 p>0.05). Conclusion: VEGF and IGF-1 levels in controlled type 2 DM tend to be lower compared to uncontrolled type 2 DM. IGF-1 levels in obese type 2 DM are lower than those who are not obese.