Pengaruh Serum Antibodi CagA Helicobacter Pylori dengan Lesi Prakeganasan Gaster pada Penderita Helicobacter Pylori

Abstract

pathogenic bacterium found in the gastric mucosa that causes chronic gastritis and gastric cancer. There are some factors of variation in the infection such as differences of the virulence of H. pylori strains, host factors, environment and diet. One of the most studied virulence factors of H. pylori is CagA protein. Several studies have shown that anti-CagA antibodies increase the risk of malignancy in the stomach. Research on this marker is rarely carried out in Indonesia because endoscopy services are still limited. The aim of this study was to determine the relationship between Helicobacter pylori CagA antibody serum and gastric premalignant lesions in Helicobacter pylori patients. Method: This was a cross-sectional and analytic research. The sample of this study were patients diagnosed with Helicobacter pylori at Haji Adam Malik General Hospital in Medan who corresponded the inclusion criteria. The research was conducted from January to December 2022. The sampling technique used was consecutive sampling. Selected subjects underwent endoscopy and biopsy, as well as antibody detection of CagA, then the data analysis was carried out. Results: The number of samples that included in this study were 60 people. Based on demographic characteristics, the majority of patients were women, Batak ethnic, having a normal body mass index, not having a history of alcohol consumption, and non-smokers. The majority of people with Helicobacter pylori did not have CagA antibodies. There was a significant relationship (p=0.009) between antibody of CagA and gastric premalignant lesions, as well as the prevalence ratio is 2.6. Conclusion: There is a relationship between antibody of CagA and gastric premalignant lesions in patients with Helicobacter pylori.