Rasio Monosit Limfosit sebagai Faktor Prognostik Mortalitas pada Pasien Hemodialisis Reguler di RSUP H. Adam Malik Medan

Abstract

Introduction: Chronic Kidney Disease (CKD) has become world health problem with high morbidity and mortality rate. In CKD, chronic inflammation occurs, one of the causes including factors related to dialysis. Monocyte Lymphocyte Ratio (MLR) is a new hematology marker associated with tumor, inflammatory disease, and cardiovascular disease. MLR is also a prognostic of infection complication in hemodialysis patient. The aim of this study is to assess the accuracy of MLR as prognostic of mortality in regular hemodialysis patient at RSUP H. Adam Malik Medan Method: This study is an analytic retrospective cohort study of CKD patient who undergoes regular hemodialysis, conducted in July-December 2023 at RSUP H. Adam Malik Medan. Data were analyzed using SPSS program. Bivariate analysis was conducted to assess the correlation between the two variables. Then, ROC analysis was performed to assess the MLR as a prognostic factor of mortality. Result: Total subject in this study was 60 regular hemodialysis patients with majority of the subject was male (88,3%), the mean age was 49,77± 13,09 years old and the mortality in this study was 16,7%. The median MLR value in this study was 0,345 (0,11-1,65). This study showed a significant relationship between MLR and mortality (p=0,003). MLR showed moderate performance to predict 30-days mortality in regular hemodialysis patients (AUC=74,4%). Conclusion: MLR has moderate accuracy in predicting 30-day mortality in regular hemodialysis CKD patients.