Efektivitas Nanoherbal Haramonting (Rhodomyrtus Tomentosa (Aiton) Hassk.) terhadap Gambaran Histologi Paru-Paru Tikus (Rattus Norvegicus L.) yang Dipaparkan Allethrin

Abstract

Electric mosquito repellent is one of the factors that can increase the levels of free radicaIs, it can affect lung heaIth because it contains of allethrin. Free radical levels can be reduced by administering antioxidant compounds. Haramonting comprises secondary metaboIites such as fIavonoids, tannins, and quinones, which have function as natural antioxidants. This study aims to determine the effect of administering nanoherbaI haramonting leaves on the morphology and the histoIogy of the lungs of rats exposed by allethrin. The research design used a CompIetely Randomized Design (CRD) encompassed of five treatment groups. The treatments are K(-) (only exposed to allethrin), K(+) (exposed to allethrin and given vitamin C), and three treatment groups exposed to allethrin and given nanoherbal haramonting leaves at doses of P(1), P(2), and P(3) (100, 200, and 300 mg/kgBW). This study used 25 male white rats (Rattus norvegicus) weighing approximately 150 gram as the samples. The observations included the morphology and histology of the rats' lungs. Morphological observations included lung color and weight. The histological observations entailed the aIveolar membrane, the aIveolar Iumen, and the interaIveolar connections. The resuIts showed, the administration of nanoherbal haramonting leaves at a dose of 200 mg/kgBW was the best dose, as indicated by an increase in lung weight, pink lung color, intact and nucleated alveolar membranes, rounded alveolar lumens, and tight inter-alveolar connections.