Perbandingan Pemberian Ceramide terhadap Tingkat Hidrasi Kulit pada Dermatitis Atopik dan Diabetes Melitus

Abstract

Background: Xerosis cutis is condition related to a decrease in natural barrier function or a lack of moisturizing factors in skin, which causes decrease in skin hydration. The diseases include atopic dermatitis and diabetes mellitus. Ceramide is physiological lipid in stratum corneum which functions to maintain the integrity of skin barrier and increase skin hydration so it is suitable for use in xerosis cutis. Objective: Determine the comparison of ceramide administration on skin hydration levels in atopic dermatitis and diabetes mellitus. Subjects and Methods: A clinical trial study with a quasi-experimental design involving 27 atopic dermatitis and 27 diabetes mellitus patients. Basic data, physical, and dermatological examination were used to determine the subjects. Providing ceramide cream for 4 weeks, measuring skin hydration levels with Corneometer CM 825® before and after the intervention, data analysis was carried out. Results: The characteristics of atopic dermatitis patients were dominated by women, 23 people (85,2%), with 17 people in the 26–35 year age group (63,0%), while diabetes mellitus patients were dominated by women, 14 people (51,9%), with the age group 46–55 years were 11 people (40,7%). The most common clinical characteristics in both patients were pruritus and xerosis. There is a significant difference on skin hydration levels between before and after administration of ceramide in atopic dermatitis and diabetes mellitus patients. Conclusion: The skin hydration levels after administering ceramide in atopic dermatitis is greater than diabetes mellitus patients.