Korelasi Kadar Profil Lipid pada Pasien Sepsis yang Dirawat di ICU RSUP H Adam Malik Medan yang Dihubungkan dengan Skor SOFA

Abstract

Background: Sepsis is a major cause of organ failure and death in the ICU. Septic patients may have impaired lipid profiles. This is presumably because during the infection process there is a significant change in lipid metabolism due to several mechanisms, including decreased hydrolysis of triglycerides and lipoproteins coupled with proinflammatory cytokines that stimulate the production of free fatty acids and triglycerides in the liver. Objective: Prove changes in lipid profile levels associated with SOFA scores in septic patients admitted to the ICU H. Adam Malik Hospital, Medan Methode: This research is an observational study with a cohort – prospective data collection method. This study took blood samples of patients who were treated in the ICU as many as 48 patients. Samples were checked for Lipid Profile on days 1 and 3, while SOFA scores were calculated on days 1 and 3. The study was carried out after obtaining ethical approval and informed consent. Result and Discussion: 24 men (50%) and 24 women (50%) with the youngest 18 years old and the oldest 65 years old. Using the Wilcoxon test showed that there was a difference in the mean of total cholesterol, LDL cholesterol and triglycerides between the first and third days (p<0.001). Using the Wilcoxon test showed that there was a difference in the mean of total cholesterol, LDL cholesterol and triglycerides between the first and third days (p<0.001). Conclusions and Suggesttion: Lower total cholesterol, HDL cholesterol and LDL cholesterol levels were found in septic patients but increased trigliseride levels were found in septic patients. The correlation between total cholesterol levels, LDL cholesterol with SOFA scores can be used to assess the severity of sepsis patients. Triglycerides can be used as a marker of worsening in septic patients