Pengaruh Rasio D-Dimer/Fibrinogen dengan Derajat Keparahan COVID 19 pada Pasien Penyakit Jantung Koroner yang Menderita COVID 19 di RSUP HAM Tahun 2021

Abstract

Background: COVID-19 is a disease caused by SARS-CoV-2 and which became a worldwide pandemic. The virus enters and forms the bonds between the spike protein on the surface of the virus and the angiotensin-converting enzyme 2 (ACE2) receptor in the lungs, heart, kidneys, blood vessels. Cardiovascular diseases such as coronary heart disease (CHD) can exacerbate the severity of COVID- 19 by triggering excessive inflammatory and coagulation responses. D- dimer/fibrinogen ratio (DFR) has been proven to be significant in assessing thrombosis. In several studies, DFR examination was considered more accurate than using D-dimer or fibrinogen examination alone. Aim: To determine the correlation between the DFR value and the severity of COVID-19 in CHD patients with COVID-19 at H. Adam Malik General Hospital. Method: This is a cross sectional study. The samples are the patients who are treated in isolation room at H. Adam Malik General Hospital who meet the inclusion and exclusion criteria. To analyze the correlation between the DFR value and the severity of COVID-19 in CHD patients with COVID-19 at H. Adam Malik General Hospital we conduct the chi-square test. Results: From 39 samples, there is a significant correlation between the DFR value and the severity of COVID-19 in CHD patients with COVID-19 at H. Adam Malik General Hospital (p=0.0001). Conclusion: There is a significant correlation between the DFR value and the severity of COVID-19 in CHD patients with COVID-19 at H. Adam Malik General Hospital.