Perbandingan Pemberian Magnesium Sulfat 30 Mg/KgBB dengan Lidokain 1,5 Mg/KgBB terhadap Perubahan Respon Hemodinamik dan Kadar Kortisol Paska Intubasi pada Pasien yang Menjalani Kraniotomi

Abstract

Introduction In craniotomy, stress responses can occur from increased hemodynamics to hormonal stress responses such as increased cortisol levels. Intubation is a major factor that must be considered during the induction of neuroanesthesia. Endotracheal intubation is an important component of general anesthesia in craniotomy surgery. Magnesium sulfate has advantages in terms of maintaining the stability of brain autoregulation and is neuroprotective. Method Magnesium sulfate has advantages in terms of maintaining the stability of brain autoregulation and is neuroprotective. With a minimum total sample for the entire group of 30 samples which were divided into 3 groups of patients who received lidocaine, MgSO4 and a control group who received NaCl 0,9% Results There were significant differences between the three groups with hemodynamic and serume cortisol values found to be lower in the lidocaine group Conclusion Intravenous administration of Lidocaine 1.5 mg/kgbb is most effective in attenuating the stress response in the form of increased blood pressure, HR and serum cortisol levels due to laryngoscopy and intubation in patients undergoing craniotomy compared to intravenous administration of MgSO4 30 mg/kgbb