Formulasi dan Karakterisasi Self Nanoemulsifyingdrug Delivery System (SNEDDS) Vitamin E

Abstract

Background: Vitamin E is efficacious as an antioxidant that can fight free radicals, but has solubility in water and poor stability that causes low bioavailability. Therefore, a preparation of Self Nano-emulsifying Drug Delivery System (SNEDDS) from vitamin E was made to overcome these problems. Objective: This research aims to formulate vitamin E into SNEDDS dosage form, characterize, and determine the antioxidant activity of SNEDDS vitamin E. Methods: Preparation of SNEDDS containing vitamin E with various oils (canola oil, olive oil, palm oil, soybean oil, sunflower oil, and virgin coconut oil) with the ratio of oil: Tween 80: Span 80, which is 4:4:3 in 30 ml. Furthermore, characterization was carried out including organoleptic, density, particle size, zeta potential, drug content, and stability testing. In addition, the antioxidant activity of SNEDDS was tested using DPPH (2,2-diphenyl-1-picrylhydrazyl) method. Results: From the results of the study, it was obtained that vitamin E can be formulated into SNEDDS preparations. From the characterization results, the smallest particle size was obtained in formula 5 (SNEDDS -sunflower oil) of 99.30 ± 16.20 nm, while the largest size, namely formula 3 (SNEDDS -palm oil) of 438.38 ± 12.21 nm. All SNEDDS of vitamin E preparations have met the requirements, which are in the range of 97.77%-99,35%. SNEDDS of vitamin E is classified as a strong antioxidant and the formula that has the best antioxidant activity is formula 5 (SNEDDS -sunflower oil) with an IC50 value of 64.8454 μg/ml. Conclusion: Based on the results of the study, it can be concluded that vitamin E can be formulated into SNEDDS preparations with nanometer-sized particles and the preparations have strong antioxidant activity.