Penurunan Potensi Interaksi Obat pada Pasien Diabetes Melitus Tipe 2 Rawat Jalan dengan Intervensi Apoteker di Rumah Sakit Prof Dr. Chairuddin Panusunan Lubis Medan

Abstract

Background: Type 2 diabetes mellitus (T2DM) often experiences complications resulting in taking more than 2 medications and the potential for unexpected drug interactions. So the role of pharmacists is very much needed in preventing and reporting effects that can occur from drug interactions. Objective: To determine the effect of pharmacist intervention on potential drug interactions in outpatient T2DM patients at Prof. Dr. Hospital Chairuddin Panusunan Lubis (RSCPL) Medan. Method: Using descriptive methods. The sampling technique was random sampling, data was obtained from medical records before the intervention in April 2023 and after the intervention in July 2023, the intervention was carried out by providing brochures and interviews for 3 months, then analyzed using a drug interaction checker and processed statistically using the Wilcoxon test. Results: From 106 medical records, before the intervention there were 63 potential prescriptions, 124 potential drug interactions occurred after the intervention, decreasing from 61 potential prescriptions to 107 incidents. The results of the Wilcoxon test obtained a p value of 0.000, it was concluded that pharmacist intervention was able to reduce the potential for drug interactions. Based on pharmacodynamic interactions before intervention, namely 104 events, after intervention it decreased, namely 92 events, and pharmacokinetic interactions before intervention, namely 20 events, after intervention decreased, namely 15 events. The highest level of severity was medium before the intervention, 107 incidents, after the intervention it decreased to 93 incidents. Conclusion: Pharmacist intervention influences the reduction of potential drug interactions based on pharmacodynamic and pharmacokinetic mechanisms, and also the severity of intermediate drug interactions.