Potensi Ekstrak Daun Sirih Cina (Peperomia Pellucida L.) terhadap Histologi Organ Hati Mencit (Mus Musculus L.) yang Dipapar Asap Rokok

Abstract

Free raldicalls produlced from cigalrette smoke caln calulse dalmalge to the liver. Liver dalmalge dule to free raldicalls caln be trealted by aldministering alntioxidalnts which coulld be foulnd in the sirih cinal plalnts. Sirih cinal lealves (Peperomial pellulcidal L.) contalin compoulnds in the form of flalvonoids, terpenoids, allkalloids, talnnins alnd essentiall oils als naltulrall alntioxidalnts thalt caln be ulsed to improve the strulctulre alnd histology of the liver. This resealrch alims to determine the potency of the sirih cinal lealf extralct (Peperomial pellulcidal L). on the histology of the liver of mice (Muls mulsculluls L.) exposed by cigalrette smoke. This resealrch method ulsed al completely ralndomized design (CRD) consisting of 6 trealtments ealch, which were the control withoult alny trealtment; the exposulre by cigalrette smoke only; the exposulre to cigalrette smoke alnd being given vitalmin C; the exposulre to cigalrette smoke alnd given sirih cinal lealf extralct alt doses of 50, 70 alnd 90mg/KgBW. This resealrch ulsed salmples of 24 malle mice (Muls mulsculluls L.) als testing alnimalls. The observaltions malde were morphology (the weight, the color alnd the sulrfalce of the liver) alnd allso histology (the normall hepaltocyte cells, the palrenchymaltouls degeneraltion, the hydrophic degeneraltion alnd the necrosis).The resealrch resullts show thalt sirih cinal lealf extralct alt al dose of 90mg/KgBB improve the morphology of mice livers, nalmely the color, the weight alnd the sulrfalce of mice livers. Aldministraltion of sirih cinal lealf extralct alt doses of 50mg/KgBW alnd 70mg/KgBW give no significalntly improve to the liver histology of mice. Sirih cinal lealf extralct alt al dose of 90mg/KgBW significalntly improve the liver histology of mice by redulcing the dalmalge to the hepaltocyte cells thalt experienced palrenchymaltouls degeneraltion alnd necrosis dule to exposulre by cigalrette smoke.