| dc.description.abstract | Background: Data of the International Diabetes Federation (IDF) in 2021,
Indonesia ranks fifth with the number of diabetics of 19.47 million with the
prevalence of diabetes in Indonesia of 10.6%. This is estimated to increase to 592
million in 2035. The increase in cases of diabetes mellitus from year to year
suggests that serious attention is needed in the treatment of the disease. The use of
traditional medicine is one of the alternatives in the treatment of diabetes. The
ability of the dragon’s skin to lower blood glucose levels is due to its antioxidant
activity, especially the flavonoid content of the fruit. The red dragon skin has the
strongest antioxidative activity among other parts, which is 85.32 10.24 using
ethanol solvent. The flavonoid mechanism in dragonfruit skin, especially quercetin,
in lowering blood glucose levels, is to inhibit GLUT 2 of the intestinal mucosa,
which can decrease glucosa absorption.
Objective: This study aims to find out the content and effectiveness of the extract
of the dragon skin (Hylocereus polyrhizus) in providing a decrease in blood glucose
levels.
Methods: This study was conducted experimentally using 25 male mice. The
animals were first adclimatized and then measured their initial oral glucose
tolerance. The mice were modeled for hyperglycaemia by induction of 20%
fructose solution in doses of 2 g/kgBW for 4 weeks, followed by blood glucose
levels. Data analysis using the ONE WAY ANOVA test and continued with the
post-hoc Tukey HSD test.
Results: Results show that treating with dragon fruit peel extract of 100, 200, and
400 mg/kgBW is able to lower animal blood glucose levels, after induction of 20%
fructose solution.
Conclusions: The results of the study concluded that the extract of dragon fruit peel
(Hylocereus polyrhizus) doses 100, 200 and 400 mg/kgBW had effectiveness as a
reduction in blood glucose levels in test animals induced by 20% fructose solution
and doses of 200 mg/kgBW had an effect of decreasing blood sugar levels that was
almost equal to a positive control. | en_US |
