Perbandingan Serum Melatonin Sebelum dan Sesudah Suplementasi Melatonin terhadap Kualitas Tidur dan Luaran Klinis Stroke Iskemik Fase Akut

Abstract

Background : Melatonin is a hormon created by pineal gland to help initiate and maintain a sleep state. Melatonin according to previous research has been found to promote neuroplasticity and acted as an antioxidant that leads to reduced infarct volume in ischemic stroke model rats. Objectives : To observe changes in Melatonin serum level of acute ischemic stroke patients after Melatonin 10 mg supplementation for 7 days and its relationship to the improvement of sleep quality and clinical outcome Methods : This research was conducted in quasi experimental manner with 40 consecutive eligible subjects obtained from two different hospitals in Medan. All subjects received pre- and post-supplementation assesment of serum Melatonin, PSQI score and NIHSS score. Statistical analysis thus performed to determine demographic characteristics, comparison of serum Melatonin level before and after supplementation, and its relationship with changes in PSQI score and NIHSS score. Results : Majority of subjects were male (52,5 %), had Batak ethnicity (52,5%) and median age of 58,5 years old. There was a difference in median Melatonin serum levels of day 1 (75,55 pg/mL) compared to day 7 (84,46 pg/mL) although not statistically significant (p = 0,307). There are no significant relationship between delta value of serum Melatonin towards PSQI (p = 0,198 ; r=0,208) and between delta value of serum Melatonin towards NIHSS (p = 0,890 ; r=-0,023) amongst subjects. No serious adverse effects were reported. Conclusion : Serum Melatonin did increased after 7 days supplementation of Melatonin. No relationship was found between changes in Melatonin serum towards sleep quality and ischemic stroke severity.