| dc.description.abstract | Background: Skin aging is a process that takes place progressively, multifactorial, and
complex. Mango (Mangifera indica L.) originates from South and Southeast
Asia. Mangifera indica L. var. kelong is a mango variety cultivated in North Sumatra.
Mango leaves contain polyphenols, namely mangiferin, which plays a role in
improving the appearance of aging skin with antielastase, anticollagenase,
antihyaluronidase, and antityrosinase effects.
Objective: aimed to evaluate the effects of a 3% mango leaf extract cream (Mangifera
indica L. var. kelong) on facial skin aging.
Subjects and Methods: We conducted this pre-experimental clinical trial research
with a pretest-posttest design on 40 subjects with aging facial skin. We confirmed the
diagnosis through history and clinical evaluation using the dermoscopic photoaging
scale (DPAS) and skin analyzer before and after administering 3% mango leaf extract
cream at weeks 0, 2, 4, 6, and 8. During the study, we recorded side effects and assessed
the level of satisfaction at the end of the research period. To determine the differences
before and after treatment, we conducted the repeated ANOVA and Friedman test,
considering a p<0.05 as significant.
Results: There was a statistically significant reduction in the DPAS score in subjects
with facial skin aging after 8 weeks of applying a 3% mango leaf extract cream.
According to the skin analyzer, there was a significant reduction results for spot
evaluation, roughness, and ultraviolet moisture, while wrinkles, ultraviolet damage,
and ultraviolet pigmentation showed a decrease in mean results, although not
significant. All subjects found the 3% mango leaf extract cream satisfactory and did
not experience any side effects.
Conclusion: The use of 3% mango leaf extract cream can improve the appearance of
aging facial skin without side effects and good level of satisfaction. | en_US |
